Effect of Hypoxia Inducible Factor on Hypoxia Inducible Gene Expression and Glycolysis

Aim: The effect of both HIF-1 and HIF-2 drastically affect hypoxia responses. Because the relative contributions to hypoxic gene induction and transcriptions are unknown; we aim to evaluate HIF2 target genes, and discuss the secondary gene activations and RNA expression transcripts.

Place and Duration of Study: This study was carried out in the Department of Biochemistry, Faculty of Science, Center of Innovation in Personalized Medicine, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia, in the year 2015.

Methodology: Both HIF-1α and HIF-2α have been implicated in hypoxia responses. However, till now, their relative contributions to hypoxic gene induction and transcriptions is unknown. Here in this study we evaluate HIF2α target genes, and discuss the secondary gene activations and RNA expression transcripts, specifically glycolytic genes and we believe such information can translate into further hypothesis generating studies that could result in oncology and drug discoveries.

Results: This study showed that, HFI1α stimulates glycolytic GE in both types of cells clearly showing for the HFI1α and HFI2α (or HFI1 and HFI2) have singular aims; however, growing proof distinguishes between both molecules in terms of transcriptional targets and effect on different physiological pathways and tumorigenesis. Moreover, more interest has been paid in order to understand the real effect of HFI2a in order to control/regulate different sides of digestive-tumors; including angiogenesis, proliferation and apoptosis, metastasis, metabolism and resistance to chemotherapy.

Conclusions: The study shows that HFI2α plays an essential and crucial role as regulator of the malignant phenotype. In the present study, one shows the importance role played by both HFI1 and 2 through tumor growth.