Spiradenoma: A Case Report with Evidence Reinforcing the Thickened Nerve Fibers in the Tumor Capsule

Aim: Spiradenoma is a rare tumor. Spontaneous pain and tenderness on palpation is a frequent symptom of the disease. Although the cause of pain in spiradenoma is not clarified yet, thickened nerve fibers in the capsule of tumor have been suggested to be related to the pain symptoms.

Case: We here report a woman with painful nodules on her abdomen for two months. The histopathological examination confirmed the diagnosis of spiradenoma. Immunohistochemically the tumor nodule and capsule were both S-100 positive, whereas the neuron specific enolase stained only the capsule of the tumor.

Discussion: Although further studies are required to explain the exact mechanism of pain in these tumors, by reporting this case, we provide additional evidence for the existence of thickened nerve fibers in the capsule of spiradenoma.