Early Exposure to Polyphenol-Rich Sugarcane Extract (PRSE) Mitigates Aging While Enhancing Thermotolerance in C. elegans

Heydarian, Deniz and Flavel, Matthew and Munasinghe, Mihiri and Almotayri, Abdullah and Jois, Markandeya and Thomas, Jency (2024) Early Exposure to Polyphenol-Rich Sugarcane Extract (PRSE) Mitigates Aging While Enhancing Thermotolerance in C. elegans. Journal of Ageing and Longevity, 4 (1). pp. 15-27. ISSN 2673-9259

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Abstract

Previous research has established that polyphenols increase lifespan and stress resistance in C. elegans. However, the effects of timing of exposure on the extension of lifespan and the mechanisms involved are not completely understood. This study aims to clarify the influence of the timing of polyphenol-rich sugarcane extract (PRSE) administration on the lifespan of Caenorhabditis elegans. C. elegans worms were subjected to a diet containing PRSE powder at various larval stages until their death. The optimal concentration for lifespan extension was found to be 5 mg/mL PRSE, which increased the lifespan of N2 worms by 18.12% compared to the control group. Mutant strains were also tested, and worm thermotolerance assays were used to assess age-related health at different life stages. Lifespan was notably extended when PRSE was introduced at the first larval stage and 15 h thereafter. No significant extension of lifespan was observed when introduced later in life. The lifespan of DAF-16 and DAF-2 mutants remained unaffected by PRSE. Improved thermotolerance was observed, especially in young and middle-aged worms. Early initiation and sustained intake of PRSE might improve the heat stress and lifespan, implicating the insulin/IGF-1 signaling pathway as a likely mediator in C. elegans.

Item Type: Article
Subjects: OA Open Library > Multidisciplinary
Depositing User: Unnamed user with email support@oaopenlibrary.com
Date Deposited: 27 Feb 2024 05:19
Last Modified: 27 Feb 2024 05:19
URI: http://archive.sdpublishers.com/id/eprint/2536

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