PRODUCTION OF TERREIN ANTIBIOTIC AND EXAMINATION OF ITS ANTIMICROBIAL ACTIVITY ON SOME SELECTED MICROBIAL SPECIES

Antibiotics used for the treatment of a infection (bacterial and fungal infection) and their substantial production in worldwide has resulted in their easy availability. The antibiotic (Terrein) developed recently, although approved by the FDA (Food and Drug Administration), are not currently available in the market. Therefore, this study aimed to produce antibiotics (Terrein) from the actual source (organisms) in the laboratory. In this study, we targeted Aspergillus terrus, ubiquitous filamentous fungus usually isolated from soil rhizospheres. Aspergillus terrus is the unique Aspergillus species producing Terrein as one of its extensive secondary metabolites. A series of recent studies stated that the economic importance of Terrein as an inhibitor of plant growth. Furthermore, a series of essential biological activities have been associated with Terrein, such as antimicrobial, antiproliferative and antioxidative activities. In our study, we analyzed that the antibiotic produced in our fermentation media was more effective against Aspergillus niger, Escherichia coli, Staphylococcus aureus and less effective against Bacillus subtilis and Pseudomonas aeruginosa, and the same antibiotic produced using Czapek-Dox agar media was more effective against A.niger and E. coli and less effective against S. aureus and P. aeruginosa. The ciprofloxacin showed very appreciable results in all the plates. Antibiotic Terrein inhibits age-related inflammation and also response for metabolite strength such as anticancer properties and hypopigmentary effect.