Study on Phytoestrogen and Gut Micro-Biome Composition of Women with PCOS

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 15% of reproductive aged women. Affected women exhibits the clinical features such ovulatory dysfunction, insulin resistance hyperandrogenism and obesity. Etiology still remains unclear but genetic and lifestyle factors contributing to the etiology of PCOS has been evidenced by many research studies. However its exact pathogenesis needs to discovered. The gut micro biota plays an important role in human health. Occurrence of altered gut micro biome composition and dysbiosis has been observed among women with PCOS. Phytoconstituents like phytoestrogen- a plant derived nutritive bioactive compound which mimics the similar structure and activity of estrogen hormone. It aids in alleviating the symptoms of PCOS without any adverse effects such as improve the ovulation and to reduce blood glucose. It also helps to improve the gut micro biome composition by increasing alpha and beta diversity. The main objective of this chapter is to explore the innumerable findings between the association between the Phytoestrogens, PCOS and gut micro biome composition.