Comparative Evaluation of the Synbiotics, Antibiotics and Analgesics in Post Extraction Healing of Tooth Sockets

Background: In the current scenario, the emergence of antibiotic resistance and its side effects have limited their use in a range of prophylactic options. Indeed, some new strategies and alternative therapies, such as herbal medicines and laser therapies, have already reduced the use of antibiotics to prevent/cure health problems or oral diseases. Many authors are currently attempting to demonstrate the influence of synbiotics in the maintenance of oral health, so this study was conducted to examine the use of synbiotics and their benefits in the post-extraction tooth socket.

Aim: The aim of this research is to study the Clinical effectiveness and cost-effectiveness of synbiotics over antibiotics and analgesics in post extraction of tooth socket

Materials and Methods: This research is a randomised controlled trial, parallel group, multicenter trial comparing the effectiveness of synbiotics in post-extraction socket healing that was conducted in three locations in Lucknow, India, including the BBD dental college of dental sciences. There were three groups of 80 patients each. On the third, fifth, and seventh days, the primary outcome measures were observed in each group.

Results: In terms of the evaluated parameters, we discovered a significant difference between the three groups. Table 1 show the age and gender distribution. Wound-related complications such as bleeding, swelling, and gut flora disturbance at the surgical site were more prevalent in groups 2 and 3 than in group 1, which was found to be statistically significant with p values of 0.02, 0.01 and 0.01. Table 5 show the cost analysis of the study subjects during treatment, with statistically significant results obtained between groups 1 vs group 2; group 1 vs group 3; and group 2 vs group 3 at p 0.01.

Conclusion: Since this was a novel approach to comparing post-extraction wound healing, and the results demonstrated a definite positive effect by synbiotics. Synbiotics hold a promise in improving oral health. Further research with a larger sample size and a different formulation would be recommended before putting the product into clinical use.