Detection of BRCA2 Receptor Gene Polymorphism in Sudanese Patients of Prostate Cancer in Khartoum State

Back Ground: Prostate cancer (PCa) is a genetically complex disease with multiple predisposing factors affecting presentation, progression, and outcome. This was analytical case-control study conducted between January 2019 up to January 2021.

Objective: This study was aimed to investigate the effect of BRCA2 polymorphism in the etiology of prostate cancer among Sudanese patients.

Methods: The study population was selected as one hundred patients with prostate cancer as case group and thirty healthy individuals as control. A total of 5 ml EDTA anti-coagulated venous blood samples were obtained from prostate cancer patients that admitted for routine follow-up of chemotherapy treatment, for hormones and remain of blood samples were kept at liquid nitrogen until used for DNA extraction and genes polymorphisms at institute of tropical diseases of Khartoum.

Results: One hundred and thirty persons were included, 100 patients were men with prostate cancer as case group while thirty were healthy subjects as control with mean age of case was 67.41years. The result showed that (87%) of patients with wild type BRCA2 6174delT alteration and (13%) with mutant type. The mean result of testosterone level, Insulin G. F level, and PSA level in associated to BRCA2 6174delT was insignificant difference between patients with mutant and wild genotype (P. value= 0.91, 0.061, 0.449, respectively).

Conclusion: This study was concluded the most frequent prostate cancer patients (87%) with wild type BRCA2 6174delT and there was no significant correlation in testosterone level, Insulin G. F and PSA level when correlated to BRCA2 6174delT with different genotype.